Methods of intranasal administration.doc

 PAGE \* MERGEFORMAT 7 Methods of intranasal administration [Abstract] Objective: To study the nasal delivery system an effective manner. Method: In recent years, domestic and international literature on the nasal delivery system to explain the factors affecting absorption of intranasal administration, and nasal drug delivery system of Chinese medicine in recent years, new formulations, and promote absorption of methods and development trends for a discussion. Results and Conclusion: With the right nasal delivery system for in-depth study of intranasal administration of Chinese medicine there are even broader prospects for development. [Keywords:] nasal cavity; drug delivery system; new dosage form Drugs in the nasal cavity and nasal absorption of Nei Jing to play the role of systemic or local therapeutic agents, known as nasal drug delivery system (Nasal Drug Deliever System, NDDS). With new accessories and new technology, to play the role of systemic treatment of nasal drug delivery preparation of more and more attention. In this paper, the factors that affect the absorption of intranasal administration [1-5], to improve the absorption of intranasal administration methods and trends in the development of intranasal administration to make a set. A change in method of nasal absorption of drugs 1.1 Absorption enhancers for nasal drug delivery have been identified, there is the promotion of the role of absorption enhancers include: sodium cholate (C), Gly-cholate (GC), sodium taurocholate (TC), sodium deoxycholate ( C), licorice Pavilion sodium, carbon-ene-oxo-disodium salt, tauro-ADM-dihydro-steroidal acid sodium (STDHF), dihydro-ADM-steroidal acid sodium; α , β , γ -cyclodextrin and its derivatives, etc. ; certain carrier materials such as Kappa mother, transparent resin sodium there is a certain role in the promotion of drug absorption [6]. Bile acid and its derivatives to promote nasal absorption of drugs also has a very good role [7]. According to the n