Metoprolol spironolactone treatment of dilated cardiomyopathy and heart failure observation.docVIP

 PAGE \* MERGEFORMAT 9 Metoprolol spironolactone treatment of dilated cardiomyopathy and heart failure observation [Abstract] Objective To observe metoprolol spironolactone dilated cardiomyopathy with chronic heart failure patients. Methods 60 patients with dilated cardiomyopathy and chronic heart failure patients were randomly divided into two groups, control group of 30 patients, to diuretics, digitalis, angiotensin converting enzyme inhibitor (ACEI) and nitrate preparations conventional treatment, 30 cases observed in the control group based on the use of metoprolol, each time by a small dose of 6.25 mg, 2 times / d started 1 week dose was doubled, reaching 50 ~ 100 mg / d, while adding spironolactone 20 mg, 2 times / d, more than 6 months long-term use, so that resting heart rate of not less than 55 times / min, systolic blood pressure gt; = 90 mmHg. respectively, before treatment and 6 months underwent color Doppler cardiac patients were left ventricular fractional shortening (FS), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVDD) , left ventricular end systolic diameter (LVESD), heart rate (HR), cardiac effects were observed. The results observed total effective rate was 93.3% in the control group, the total effective rate was 60.0%, total effective rate between the two groups was statistically significance (P lt;0.01). after treatment group, FS, LVDD, LVESD, and HR compared with control group there was significant difference (P lt;0.05 or 0.01), the two LVEF was no significant difference (Pgt; 0.05). Observation group heart rate, improve the FS, LVESD decreased LVDD and superior to the control group. Conclusion metoprolol spironolactone treatment can significantly improve heart failure patients with dilated cardiomyopathy and cardiac function and attenuates myocardial remodeling. [Keywords:] metoprolol; heart disease; myocardial remodeling; heart function With better understanding of the pathogenesis of he