Microdialysis application of advances in neurosurgery.docVIP

 PAGE \* MERGEFORMAT 15 Microdialysis application of advances in neurosurgery [Keywords:] Microdialysis monitoring of neurological surgery Microdialysis (microdialysis, MD) technique was originally envisaged by Delgado and Ungerstedt, they break the traditional thinking bio-sensors, so that biochemical analysis carried out by the body transferred to in vitro. In 1966, Bito containing 6% dextran of the dialysis membrane bags into dog brain hemisphere, 10 w bag removed after analysis of amino acids. The 20th century, 70’s, this technology shaping the modern MD, perfusion fluid into the brain tissue in the semi-permeable membrane tube in the process flow and brain interstitial fluid (ECF) between the penetration of the brain tissue in order to achieve a continuous interstitial fluid sampling. The 20th century, 90’s, MD clinical success and the production of catheters bedside dialysate analyzer (CMA Microdialysis, Solna, Sweden) the clinical introduction so that it began to be used. 1 MD Technology 1.1 MD Principles of MD, including a double-lumen catheter probe tip is a semi-dialysis membrane. After the probe into biological tissue through the lumen perfusion fluid and, when the infusion fluid through the dialysis membrane, the membrane on both sides spread of substances in dialysate from the drain tube into the collection container. MD catheter is why a man like capillaries, the concentration of substances in dialysate relies in part on the proliferation of film on both sides of the material balance, while also relying on material in the tissue fluid in the intake and supply. For example, capillary blood flow reduction and / or cells to increase glucose uptake analysis of fluid can lead to lower sugar concentration. Dialysate concentrations of substances in interstitial fluid in the ratio of the actual concentration is called the relative recovery rate, recovery rate high or low depends on the membrane pore size, membrane area, perfusion flow and material