MMP-9 gene polymorphism and the development of gastrointestinal cancer research progress in.doc

 PAGE \* MERGEFORMAT 13 MMP-9 gene polymorphism and the development of gastrointestinal cancer research progress in [Abstract] matrix metalloproteinase-9 (Matrix Metalloproteinase-9, MMP-9) is a member of the MMP family, and its gene polymorphism in the tumor plays an important role in the development process. In this paper, it is easy in gastrointestinal tumors sensibility, the role of metastasis and invasion, and prognosis were reviewed. [Keywords:] MMP-9, gene polymorphism, gastrointestinal tumors MMP-9, also known as gelatinase B, is a kind of calcium and zinc ions containing protease in the extracellular matrix (Extracellular Matrix, ECM plays an important role in metabolic regulation. The role of a variety of substrates, including gelatin, flexible protein, IV collagen, V collagen and other adhesive proteins. In physiological conditions, the activity of MMP-9 is strictly regulated to zymogen form of endocrine cells into the extracellular from the post after a series of enzymatic process is activated, but in the vascular or organization activity was significantly increased in the reconstruction process [1]. The human genome has not yet found MMP-9 defects, but found a number of MMP-9 gene polymorphisms [1]. MMP-9 gene expression in the gastrointestinal tract may be closely related to tumor biological behavior. MMP-9 gene polymorphism may lead to activity or function through the change, thereby affecting the individual susceptibility to cancer, invasion and metastasis, prognosis. Therefore, to further investigate the MMP-9 gene polymorphism and gastrointestinal cancer the role of the development of relations of gastrointestinal cancer diagnosis, treatment and prognosis of great significance. 1MMP-9 and MMP-9 gene expression 1.1MMP-9 gene single nucleotide polymorphisms (Single nucleotide polymorphisms, SNPs) are the most common genetic form of polymorphism, SNPs in the population frequency of greater than 1% change in the structural genes