Modified Shixiaosan on myocardial ischemia-reperfusion injury mechanism.docVIP

 PAGE \* MERGEFORMAT 12 Modified Shixiaosan on myocardial ischemia-reperfusion injury mechanism Of: Cao Zhi Ran, Wang Bei, Shen Wen increase, Rong Snow, Pan Ying, Zhang Qiuyan, Tang Zhiyuan, Zhu Feng days [Abstract] Objective Modified Shixiaosan on myocardial ischemia reperfusion injury of the mechanism. Methods in Japan 40 rabbits were randomly divided into 5 groups: sham operation group, model group, Modified Shixiaosan low dose group, Shixiaosan in Modified Modified Shixiaosan dose group and high dose group. by ligating the left anterior descending coronary artery was prepared ischemia and reperfusion model, by testing before ischemia, ischemic reperfusion 60min 30min and the serum super oxide superoxide dismutase (SOD, malondialdehyde (MDA and serum creatine kinase (CK, and to explore Shixiaosan Modified on myocardial ischemia-reperfusion injury mechanism. Results Ischemia 60min, 30min and reperfusion model group animals The SOD activity was significantly lower than the sham group and MDA and CK were significantly higher (P lt;0.01, each treatment group in serum SOD activity was significantly higher than the untreated group, MDA and CK activity was significantly lower than model group (P lt;0.01, and were dose dependent. Conclusion Modified Shixiaosan on myocardial ischemia-reperfusion injury has a protective effect, the mechanism is through the enhancement of SOD, scavenging free radicals and reduce the myocardial injury. [Keywords:] Modified Shixiaosan, ischemia and reperfusion, superoxide dismutase, malondialdehyde, serum creatine kinase Abstract: ObjectiveTo study the protective mechanism of Jiawei Shixiaosan in isocheimmia-reperfusion injury of myocardia in rabbits.MethodsForty rabbits were divided randomly into 5groups: sham operation group, model group, low dose group of Jiawei Shixiaosan, middle dose group of Jiawei Shixiaosan and high dose group. The isocheimmia and isocheimmia-reperfusion models were made by ligating the left anterior