Molecular imprinting technology in the extraction and separation of traditional Chinese medicine.doc

Molecular imprinting technology in the extraction and separation of traditional Chinese medicine [Key Words] molecular imprinting technology, medicine, extraction, review Molecular imprinting technology (molecular imprinting technology, MIT) is a late 20th century the emergence of a highly selective separation technology, which stems from the basic idea is that people on the antibody - antigen specific knowledge, the use of polymer with molecular recognition physical materials - molecular imprinted polymer (molecule imprinting polymer, MIP) to separate, filter, purify compounds a bionic technology. because the preparation of the material has a high selectivity and molecular recognition of outstanding performance, quickly in the solid phase extraction, artificial enzymes, chiral separation, biosensors, asymmetric catalysis has been widely used. The author is mainly on the MIT in the extraction and separation of traditional Chinese medicine are reviewed. A basic principle of molecular imprinting technique and the preparation of polymers 1.1 Basic Principles MIT is the choice of specific molecules can interact with the imprinted functional monomer, through the role of covalent and non-covalent molecular imprinting in a solvent to form - functional monomer complex, adding crosslinker, the initiator in the initiator and with special functional groups functional monomer for the polymerization of light or heat to form a three-dimensional cross-linked polymer network, and then imprinted with a suitable solvent to remove molecules formed in the polymer network and chemical functions of space and match the template molecule hole. This hole exactly the same molecular structure with the Western blot, can be associated to the template molecule or molecules with similar structure to achieve specific recognition. 1.2 Preparation of Molecularly Imprinted Polymers Preparation of molecularly imprinted polymers can be divided into three steps: The first step is im