Model of acute cerebral ischemia Magnetic Resonance Spectroscopy Study.docVIP

 PAGE \* MERGEFORMAT 15 Model of acute cerebral ischemia Magnetic Resonance Spectroscopy Study Study: Pine Beach Bo Ye Liu Xian Zhou understand Sang Jing Deng Shigui Pond School [Abstract] Objective: To investigate the acute cerebral ischemia by magnetic resonance spectral changes. Methods: A rabbit model of acute cerebral ischemia in parallel MRS examination, in the ischemic core and the surrounding area were used to detect N-acetyl aspartate (NAA, choline Cho, creatine Cr, lactate Lac. Results: The ischemic area of #8203;#8203;the 1H-MR spectroscopy shows significant decline or disappearance of NAA, Cho, Cr also see a decline in varying degrees, but less decrease in NAA, and the ischemic core were less than the surrounding area decrease ischemic large Lac peak appears, and the highest peak Lac ischemic core, ischemic lower around the area. Conclusion: This experiment studies of acute cerebral ischemia model in rabbits MRS characteristics for the study of brain ischemic disease provide a reliable theoretical basis and experimental animal models. [Keywords:] cerebral ischemia, magnetic resonance imaging, spectroscopy [Abstract] Objective: To investigate the mechanism of Magnetic Resonance Spectroscopy and the value of Magnetic Resonance Spectroscopy in the acute cerebral ischemia. Methods: The Acute Cerebral Ischemia Model of 10 rabbits were performed on MRS. The level of NAA, Cho, Cr, Lac in the center and peripheral of the ischemic area were measured on MRS. Results: The Proton Magnetic Resonance Spectroscopy of the ischemic area showed: the level of NAA decreased obviously, the level of Cho, Cr were also decreased, and the down extent in the center of the ischemic area was bigger than that in the peripheral of the ischemic area. The peak of Lac was showed, and it was higher in the center of the ischemic area. Conclusion: Magnetic Resonance Spectroscopy can reflect injured degree of brain tissue, and biochemical event, developing regularity of cer