Molecular targeted therapy of malignant brain glioma research.doc

 PAGE \* MERGEFORMAT 31 Molecular targeted therapy of malignant brain glioma research 【Abstract】 The present study shows that malignant progression of glioma cell proliferation involved in regulating the signal channel molecules or genetic abnormalities, overexpression of oncogenes or tumor suppressor gene mutations. In recent years, research focus is targeted transduction pathways in tumor cells (including tumor growth, invasion and metastasis, etc.) on a specific or relatively specific molecular targeted therapy, is expected to be outside of the traditional cytotoxic chemotherapy treatment breakthrough. Full summary of brain tumors in recent years in research and clinical trials, application of small molecules and monoclonal antibodies literature. Keywords: Glioma Molecular targeted therapy Malignant gliomas are the most common intracranial tumor, treatment difficulties and poor prognosis. Traditional treatment method for post-operative radiotherapy and chemotherapy, comprehensive treatment. Is now clear a number of chemotherapy could prolong survival of patients with glioma, but the effect is not satisfactory. Traditional medicine to attack targets more concentrated on the active proliferation of cells, or lead to abnormal proliferation of substances, such as DNA, proteins and genes, the lack of tumor cell-specific, normal tissues and organs causing toxicity. In recent years, with the development of molecular biology techniques and from the cell receptors and proliferation of regulation at the molecular level the pathogenesis of brain glioma awareness began targeting cell receptors, the key genes and regulatory elements for the treatment of target , called “targeted therapy” [1]. The area includes a targeting of the epidermal growth factor receptor (EGFR) blockers, targeted at certain specific cell marker monoclonal antibodies against certain cancer genes and cancer genetics signs of drugs, anti-angiogenesis drugs, anti-tumor vaccines