Montelukast in children with chronic persistent asthma IL-2 tumor necrosis factor and pulmonary function.docVIP

 PAGE \* MERGEFORMAT 7 Montelukast in children with chronic persistent asthma IL-2 tumor necrosis factor and pulmonary function [Abstract] montelukast can reduce airway hyperresponsiveness, strengthen the immune factor IL-2, reduced levels of tumor necrosis factor induced by inflammation, regulating Th1 / Th2 balance. [Keywords:] montelukast IL-2 tumor necrosis factor on lung function in children with chronic persistent Pediatric hospital in October 2008 -2009 application on October montelukast sodium treatment of children with asthma, chronic persistent asthma control achieved in children with good clinical efficacy and inflammatory mediators and molecular biology from the level of the drug’s mechanism of action. 1 Materials and Methods 1.1 The source of all the cases observed in 52 cases patients were from Shandong Laiwu City People’s Hospital pediatric asthma clinic, all the observed cases are in line with the National Pediatric Asthma Collaborative Group 2008 revised diagnostic criteria of asthma, staging and disease indexing. All children with chronic illness are in duration. including 29 males and 23 females, aged 3 years to 12 years, duration 3 to 12 months. All the patients before treatment, blood, liver and kidney functions were normal cases were randomly divided .52 for the treatment group of 30 patients, 22 patients in control group. two children in the sex, age by the statistical difference was not statistically significant (Pgt; 0.05, comparable. 1.2 The control group of drug dosage and route of a single glucocorticoid (ICS) inhalation, given budesonide (AstraZeneca inhalation, 200ug / time, 2 times / day, later changed to symptom control 200ug / time, 1 time / day or every other day 1, told his mouth after smoking. the treatment group given inhaled corticosteroids based on the addition of montelukast sodium (Hangzhou MSD Pharmaceutical Co., Ltd., 3 5-year-old 4mg / times, 6 to 12 years old 5mg / times, 1 times / day