Moonlight flower bean analgesic effect of ethanol extract and its mechanism.doc

 PAGE \* MERGEFORMAT 10 Moonlight flower bean analgesic effect of ethanol extract and its mechanism Of: Tang show energy, Huang Renbin, Huang Yuanheng, pure yellow, Wang Naiping [Abstract] Objective To study the moon flower bean analgesic effect of ethanol extract and to explore its mechanism. Methods acetic acid induced writhing in mice and the mice hot plate temperature bath to observe the moon flower ethanol extract of soybean analgesic effect, while hot plate test in mice serum and brain tissue PGE2, MDA content and SOD activity. Results moon flower bean extract ethanol can significantly reduce the writhing times in mice and significantly prolonged hot plate reaction in mice temperature bath licking latency and latency in mice reduced tail, and make the hot plate in serum and brain tissue PGE2, MDA content was decreased, SOD activity was significantly enhanced. Conclusions of ethanol extract of soybean flower moon has significant analgesic effect , and its mechanism may be related to reduced PGE2 and MDA, increased SOD activity. [Keywords:] Moonlight ethanol extracts of bean flowers, analgesic, mechanism, prostaglandin E2 Abstract: ObjectiveTo investigate the analgesic effects of ethanol extract of Calonyction acculeatum Beans and its primary analgesic mechanisms. MethodsMouse twisting numbers induced by acetic acid, mouse pain threshold after heat stimulation on hot-plate and in hot-water tests were observed to investigate the analgesic effects, meanwhile, the contents of prostaglandin E (PGE2) and malondialdehyde (MAD) and the activity of superoxide dismutase (SOD) in mice serum and cerebrum were measured to explore primary analgesic mechanisms of calonyction aculeatum beans.ResultsThe ethanol extracts of Calonyction aculeatum Beans could remarkably reduce mouse twisting numbers and prolong pain thresholds, meanwhile, it also reduced the elevated MDA and PGE2 productions and enhanced SOD level in mice serum and cerebrum. ConclusionThe ethanol