Modified leptin on hepatic fibrosis TGF1 protein expression.doc

 PAGE \* MERGEFORMAT 12 Modified leptin on hepatic fibrosis TGF1 protein expression Of: Zhao Zhiyou runner-up Zhang Junjie Wu Geng Lin Geng Health WANG Guo-Yun Ting Zhou [Abstract] [Objective] Modified leptin on liver fibrosis in rat liver by carbon tetrachloride of transforming growth factor 1 (TGF 1) protein expression. [Methods] carbon tetrachloride induced rat liver fibrosis model, grouped into normal control group, model group, flavored leptin on high, medium and low dose treatment group and control group, colchicine; intragastric administration for 8 weeks; by immunohistochemistry Detection of liver protein expression of TGF 1; of serum ALT, AST levels; with picric acid Sirius red staining of collagen fibrosis were semi-quantitative score (SSS). [results] of high, medium and low dose group and colchicine alkali group the expression of TGF 1 levels were lower than the control group; by Modified leptin on the serum ALT, AST levels and liver fibrosis significantly lower SSS scores. [Conclusion] Modified inhibit leptin on liver fibrosis in rats the expression of TGF 1, to hepatic fibrosis. [Keywords:] Modified leptin on; carbon tetrachloride; rat; liver fibrosis Abstract: [Objective] To study the effects of TGF 1 of Jiaweitaohechengtang on hepatic fibrosis induced by CCl4 in rats. [Methods] Hepatic fibrosis models were induced by CCl4 in rats.All the experimental rats were divided into six groups: normal control group, model control group, colchicine positive treatment group, high dose, medium dose, low dose jiaweitaohechenqitang treatment groups.Drugs were fed on rats for 8 weeks by intragastric administration.Protein expression levels of transfer growth factors 1 (TGF 1) were determined with immunohistochemical staining method.Scores of hepatic fibrosis were assessed with semiquantitive scoring system (SSS) through tianlanghong staining. [Results] The protein expression levels of TGF 1 in the liver tissues in model control group were markedly in