Motion sickness in rat plasma levels of calcitonin gene-related peptide changes in.doc

 PAGE \* MERGEFORMAT 14 Motion sickness in rat plasma levels of calcitonin gene-related peptide changes in Authors: Xiao-Cheng Wang, FENG Li-ning, ZHANG Zuo-ming [Keywords:] calcitonin gene-related peptide; motion sickness; rat Effect of rotatory stimulation on plasma level of calcitonin generelated peptide in rats [Abstract] AIM: To explore the relation between calcitonin generelated peptide (CGRP) and motion sickness (MS) in rats. METHODS: A group of 30 rats were subdivided into 4 experimental groups and a control group with a random number table. The rats of experimental groups were treated with rotatory stimulation for 30 min. Then the plasma levels of CGRP in 4 experimental groups were measured respectively 20 min, 6 h, 1 and 3 d after the stimulation.According to the changes of rats intake of saccharin solution before and 24 h after rotatory stimulation for 15 min. Another group of 20 rats were subdivided into a group sensitive to MS and a group insensitive to MS, then the plasma levels of CGRP in the 20 rats were measured 20 min after rotatory stimulation for 15 min . RESULTS: There was no significant difference in the plasma levels of CGRP at different time points after rotatory stimulation in the first group (F = 1.105, P = 0.893); there was no significant difference in the plasma levels of CGRP between the group sensitive to MS and the group insensitive to MS (P = 0.704). CONCLUSION: The CGRP in blood plasma doesnt play an role in the pathogenesis of MS. [Keywords] calcitonin generelated peptide; motion sickness; rats [Abstract] Objective: To investigate the calcitonin gene-related peptide (CGRP) in the pathogenesis of the role of motion sickness. Methods: group 1, 30 rats were randomly divided into four experimental groups and one control group, experimental group were given 30 min rotary motor stimulation, and then each measuring four experimental animals rotation stimulation 20 min, 6 h, 1 d, 3 d, as well as the control group animals, plasm