Moxonidine uveal scleral eye drops on rabbit aqueous humor outflow pathway and mechanism.doc

 PAGE \* MERGEFORMAT 13 Moxonidine uveal scleral eye drops on rabbit aqueous humor outflow pathway and mechanism Of: PROCEEDINGS, Cui Li Jun, the right-yin dragon, Wangxiao Hua, Zhao Shiping [Abstract] Objective To investigate the I1 receptor agonist moxonidine way drops of uveal scleral changes in fluorescence intensity in different parts to study ways of moxonidine on uveal scleral mechanisms of aqueous outflow. Methods Mo Suoni order side of the eye drops , anterior chamber injection of tracer FITC BSA eyes ,2-10h frozen sections at different time points, fluorescence microscope uveal scleral fluorescence intensity in different parts ways, prazosin (@ 1 receptor antagonist), yohimbine (@ 2 receptor antagonist) and efaroxan (I1 receptor antagonist) pre-30min, moxonidine drops, observed fluorescence uveal scleral channels. Results moxonidine drops fluorescence microscope, bilateral uveal scleral pathway significantly increased the fluorescence intensity to ciliary body and suprachoroidal strong. prazosin pre-treatment group comparison of each part with the fluorescence intensity of moxonidine had no significant differences, yohimbine and efaroxan pre-treatment group than those in all parts of bilateral fluorescence intensity reduced moxonidine group, There were significant differences (P lt;0.01), yohimbine pre-treatment group than efaroxan weaker fluorescence. Conclusion moxonidine to increase aqueous outflow through the uveal scleral pathway, the synergistic effect with prazosin, yohimbine and efaroxan can inhibit the bilateral uveal scleral outflow pathway increases aqueous humor, yohimbine more significant inhibition, indicating uveal scleral outflow of aqueous channels mainly mediated by the @ 2, I1 receptors also have an effect. [Keywords:] moxonidine, Imidazoline receptor uveal scleral pathway, aqueous humor, rabbits ABSTRACT: Objective To investigate the changes of uveoscleral pathway by an I1 receptor agonist, moxonidine, and with pretreat