MT1 MMP expression in colorectal cancer and Statistical Analysis.doc

 PAGE \* MERGEFORMAT 12 MT1 MMP expression in colorectal cancer and Statistical Analysis [Abstract] Objective: To investigate the membrane-type matrix metalloproteinase 1 (membrane type 1 matrixmetallo proteinase, MT1 MMP) expression in colorectal cancer and statistical analysis. Methods: The People’s Hospital of Wuhan University from 2004 to 2009, a complete clinical and pathological data archive paraffin blocks of colorectal cancer of 40 cases and 5 cases of adjacent tissues, by immunohistochemistry SP method detected 40 cases and 5 cases of colorectal cancer tissues the expression of MT1 MMP. HPIAS 1000 using high resolution color graphic pathology report management system, MT1 MMP expression in quantitative analysis, and use SPSS11. 5 software groups immunohistochemistry positive granules, the average optical density, the positive area ratio of single factor analysis of variance and SNK (q) test. Results: MT1 MMP in colorectal cancer was highly expressed in cancer tissues showed low expression. colorectal cancer compared with adjacent tissues, the difference was significant (P lt;0.05). Conclusion: MT1 MMP degradation of ECM may be involved by tumor invasion and metastasis to detect the expression of MT1 MMP can help predict tumor metastasis, for the treatment of cancer provides a new target. [Keywords:] colorectal cancer; MT1 MMP; immunohistochemistry; statistical analysis Recent years, with the improvement of living standard and lifestyle changes, the incidence of colorectal cancer increased year by year. From the first four malignant tumors increased to 3, the developed countries like the United States estimates 56,290 people of colorectal cancer deaths , accounted for 9.9% of the total number of cancer deaths, second only to lung and ranked No. 2 [1]. but its pathogenesis is not clear at present considered to be a multi-step, multi-stage and multi-gene genetic diseases involving . MT1 MMPs most important role is to activate MMP 2 degradation