Mulberry flavonoids and polysaccharides in type 2 diabetic rats on biochemical indexes of.doc

 PAGE \* MERGEFORMAT 8 Mulberry flavonoids and polysaccharides in type 2 diabetic rats on biochemical indexes of Of: Lixian Jia Ren Liping Wang Jiaguo [Keywords:] flavonoids; polysaccharide; diabetes Diabetes is a common disease of the elderly, development of the disease and blood glucose concentrations, insulin, total cholesterol (TC), triglyceride (TG) is closely related to the change. Since the 20th century, 70 years it developed a series of treatment of diabetes natural medicine. Yoshikawa and so that love God Leaves (a traditional Brazilian natural medicine, diabetes) had significant inhibitory effect of @ glucosidase, and its hypoglycemic activity of flavonol 6 ingredients (1); lt;lt;Compendium of Materia Medicagt;gt; records, the mulberry leaf “Sunburn cooked fried drink of tea thirst” (2); domestic Chen Fujun, etc. have reported the hypoglycemic effect of mulberry leaves (3). Recent studies confirm flavonoids eliminate free radicals through antioxidant mechanisms, to maintain the structural integrity of cells, thereby reducing blood glucose levels and prevent complications (4). polysaccharide of cells to secrete insulin, to promote the use of cells to glucose, glycogen synthesis, and improve glucose metabolism, ultimately the effect of lowering blood sugar (3). To further define the role of mulberry leaves and possible hypoglycemic mechanism, this paper mulberry flavonoids and polysaccharides on blood glucose in type 2 diabetes, insulin, TC, TG to study the effects for the clinical therapy. 1 Materials and methods 1.1 Reagents and drugs Novolin R (human insulin, Novo Nordisk), trichloroacetic acid (Tianjin Chemical Reagent Company); resin AB 8 (Shanghai Reagent four plants); streptozotocin (STZ, Sigma USA company); kit (Nanjing Jiancheng Institute of Biotechnology); glucose meters and blood glucose test strips (Roche). Mulberry and 1.2 Extraction and purification of polysaccharides Mulberry 1.2.1 Extraction and purification of mul