Multidrug resistance gene expression in breast cancer and its relationship with prognosis.doc

 PAGE \* MERGEFORMAT 11 Multidrug resistance gene expression in breast cancer and its relationship with prognosis Study: Ultra-ZHAO Xiu-fang Liu Jun Zhang Jianhong Zhang Bai Rui [Abstract] Objective: To study the P gp, ToPo , GST expression in breast cancer and prognosis. Methods: 78 routine breast cancer specimens SP immunohistochemical staining. Results: P gp positive rate was 65.4% (51/78, P gp-positive breast cancer was significantly higher than stage , , P gp positive rate of 5-year survival rate was negatively correlated (P lt;0.05.GST positive rate was 70.5% (55/78 in breast cancer period of its 76.2% rate of positive expression, and clinical stage , significant difference compared (P lt;0.05, the positive rate and 5-year survival rate was negatively correlated (P lt;0.05. ToPo expression was 64.1% (50/78, clinical stage was significantly lower than the stage , . Conclusion: Chemotherapy before testing P gp, ToPo , GST of the resistance protein, in judging the prognosis and guiding chemotherapy in breast cancer have a certain value. [Keywords:] breast cancer, multidrug resistance gene, P glycoprotein, DNA topoisomerase, glutathione S transferase [ABSTRACT] Objective: To explore expression of P gp, ToPo , GST in breast carcinoma and its relationship with prognosis.Methods: Routine section preparation from 78 cases with breast cancer were measured with SP Immunohistochemistry method.Results: The positive rate of P gp is 65.4% (51/78and that in stage of breast carcinoma was obviously higher than that of stage and stage , the positive rate was negative correlation with 5 year survival rate (P lt;0.05.The positive expression rate of GST was 70.5% (55/78, that in clinical stage of breast carcinoma was up to 90.9%, and there was significant difference among clinical stage and clinical stage , (P lt;0.05, the positive expression rate was obviously negative correlation with 5 year survival rate (P lt;0.05.The positive expression rate of