儿童社区获得性支原体肺炎血清支原体.docVIP

 PAGE \* MERGEFORMAT 8  PAGE \* MERGEFORMAT 7  PAGE \* MERGEFORMAT 1 儿童社区获得性支原体肺炎血清支原体IgM抗体滴度变化的研究 ［摘要］ 目的：研究儿童社区获得性支原体肺炎血清MP-IgM的滴度变化规律，探讨其在支原体肺炎中的诊断价值。方法：采用颗粒凝集法（PA）对确诊的107例社区获得性支原体肺炎患儿进行血清Mp-IgM滴度检测，回顾分析其发病4～6天、7～14天、15～21天以及不同病情患儿血清MP-IgM滴度的变化规律，对结果进行统计学分析。结果：1.病程在4～6d、7～14d、15～21d，MP-IgM滴度≥1:160阳性率分别为34.4%、87.3%、100%。2.病程在4～14d血清MP-IgM滴度与病程呈正相关关系（r=0.670,P=0＜0.05），其回归方程为Y0=100.827+0.188X；27例病程在7/14d的双份血清标本滴度比较均有4倍或以上升高；32例病程在15～21d的血清标本，MP-IgM滴度变化无一定规律，其中20例（62.5%）较前升??、8例（25.0%）无明显变化、4例（12.5%）较前下降。3.重症组与普通组在病程的各阶段血清MP-IgM滴度无统计学意义（X2值在2.057～0，P值在0.134～1，均大于0.05）。结论：1.CA-MPP患儿血清MP-IgM滴度变化与病程密切相关，依靠单份血清诊断MP感染需结合病程；2.CA-MPP患儿病程在7/14d，双份血清比较均升高4倍或以上，提示双份血清滴度变化诊断MP感染时不必间隔2周，短期内复测有重要诊断价值；3.CA-MPP患儿病情轻重与血清抗体浓度无相关性。 ［关键字］ 肺炎支原体；CA-MPP；MP-IgM；滴度 The studies of changs of serum MP-IgM titers in children with community-acquired mycoplasma pneumoniae pneumonia ［Abstract］Objective To studies of children with community-acquired mycoplasma pneumoniae pneumonia (CA-MPP)titer variation of serum MP-IgM ,explore its diagnostic value in mycoplasma pneumonia. Metholds The serums of 107 children with CA-MPP were detected with PA. We analysed the MP-IgM titers at different time and different group after Mycoplasma pneumoniae infection.The SPSS was used to analyze the date. Result 1.Course at 4~ 6d, 7 ~ 14d, 15 ~ 21d, MP-IgM titers ≥ 1:160 positive rates were 34.4%, 87.3%, 100%, the positive rate difference was statistically significant. 2.Serum MP-IgM titers increased in varying degrees at course within 4 ~ 14d ,MP-IgM titers were positively correlated with the course（ r = 0.670, P = 0 0.05）， the regression equation was Y0 = 100.827 +0.188 X;Course in 7/14d , 27 cases paired titer have 4 times or more by 7 days. In the course of 15 ~ 21d compared to within 14d ,MP-IgM titers 20 cases (62.5%) increase over the previous,8 cases(25.0%) did not change, 4 cases (12.5%) compared to decline before. 3.In differe