Myocardial ischemia - reperfusion on mitochondria of myocardial cells and the protective effect of traditional Chinese medicine Recent research on.doc

 PAGE \* MERGEFORMAT 16 Myocardial ischemia / reperfusion on mitochondria of myocardial cells and the protective effect of traditional Chinese medicine Recent research on Myocardial ischemia due to coronary artery obstruction or coronary artery spasm Erzhi coronary blood flow caused by insufficient. Myocardial ischemia can induce myocardial dysfunction and myocardial cell injury with severe. In recent years, with in-depth study found that myocardial cell injury and necrosis, the mitochondria in the first when it is harmful, thus damage the whole cell. Mitochondrial structure and function of damage leading to ischemia / reperfusion (I / R) myocardial irreversible injury, one of the important reasons, in the mechanism of myocardial injury has a very important role. New ways of myocardial protection - mitochondrial pathway, myocardial protection has become a research hotspot. 1 mitochondria in ischemia / reperfusion in the process of change in 1.1 The production of free radicals Vandenhoek et al [1] in vitro myocardial I / R model, confirmed the mitochondrial electron transfer and free radical generation on. When the hypoxic inhibition of respiratory chain, the Coenzyme Q is reduced to half of ubiquinone, which in the course of reperfusion reaction with oxygen molecules of oxygen free radicals, resulting in a variety of highly reactive intermediate of oxygen reduction, collectively known as reactive oxygen species cluster (ROS). ROS change in respiratory chain complexes, ATP enzyme complex adenosine transferase (ANT) of the structure, so that damage to the respiratory chain activity [2]. Destruction of plasma membrane ion pumps, exacerbated ATP depletion caused by intracellular ion imbalance. And membrane phospholipid composition of unsaturated fatty acids oxidation reaction occurred, so that the membrane fluidity decreased permeability [3]. 1.2 Some scholars have speculated that mitochondrial Ca2 overload [4] In the oxygen process, due to the collapse of mito