Nacetylcysteine on acute lung injury in rats the effects of cyclooxygenase- 2.doc

 PAGE \* MERGEFORMAT 11 Nacetylcysteine on acute lung injury in rats the effects of cyclooxygenase- 2 [Abstract] Objective: To investigate the N  acetyl-cysteine (NAC) on acute lung injury (ALI) in rats COX- 2 (COX  2) the impact of further study of N  acetylcysteine on acute acute lung injury (ALI) lung tissue protective effect. Methods: Lipopolysaccharide (LPS)-induced acute lung injury (ALI) model, and then apply N  acetylcysteine to intervene. Experimental set up the control group, model group, N  acetylcysteine group, the lung injury model of rats were killed 24 h after the success, take the left lobe lung tissue. Using immunohistochemical staining to detect N  acetylcysteine on acute lung injury in rat lung tissue COX  2 expression, using HPIAS  2000 image analysis system measured COX  2 expression in the above groups, the average optical density and the average positive area ratio. RESULTS: The lung tissue of control group, the expression of COX  2 lower; model group lung tissue COX  2 expression in high; N  acetylcysteine group of lung tissue COX  2 expression in the lower. The q test test between the control group and model group, COX  2, the average optical density and the positive area ratio, a significant difference (P amp;lt;0.01), experimental control group and between groups N  acetylcysteine, COX  2, the average optical density and the positive area was no significant difference in the rate (Pamp;gt; 0.05). Conclusion: N  acetylcysteine can reduce the extent of lung injury, acute lung injury organizations play an important protective effect. [Keywords:] N  lung injury in cyclooxygenase-acetylcysteine  2 (COX  2) Acute lung injury (acute lung injury, ALI) is a kind of excessive pulmonary inflammatory response to alveolar capillary membrane injury, increased permeability, pulmonary edema, inflammatory cell infiltration and severe gas exchange impairment as the main feature [1]. N  acetyl-cysteine (NAC