Nanoemulsion in the transdermal drug delivery system overview.doc

 PAGE \* MERGEFORMAT 18 Nanoemulsion in the transdermal drug delivery system overview [Keywords:] nanoemulsion; transdermal delivery system; Application Nanoemulsion (nanoemulsion, NE) is the particle size of 10 ~ 100 nm of the milk droplets dispersed in another liquid in the form of colloidal dispersion, the emulsion droplets are mostly spherical, the transparent or translucent. Nanoemulsion has said microemulsion ( microemulsion, ME), the oil phase and water phase, surfactant and cosurfactant consisting of optically isotropic, thermodynamic and kinetic stability of the system. According to the structure can be divided into oil in water (O / W) type , water in oil (W / O) nano-and double-continuous emulsion. Yin Nami has a good local milk and transdermal drug delivery [1], from the 20th century, 90s, nanoemulsion as a transdermal delivery system studies to become a hot research pharmacy. nanoemulsion paper focuses on the characteristics of transdermal drug delivery systems, transdermal formulations of nanoemulsion main factors that promote the percutaneous absorption nanoemulsion method nanoemulsion evaluation of transdermal delivery system were reviewed. 1 nanoemulsion absorption of transdermal drug delivery system 1.1 The role of nanoemulsion penetration Nanoemulsion penetration mechanisms include: (1) to increase the solubility of drugs; (2) increasing the stratum corneum lipid bilayer fluidity; (3) the role of percutaneous absorption of hair follicles in the skin. Yu Yuan et al [2] prepared hydrochloride Methyl - lecithin nanoemulsion to methylphenidate - lecithin suspension and control solution as methylphenidate, HPLC method for the determination of drug penetration were calculated percutaneous penetration of nanoemulsion steady flow, the results show that mixed aqueous suspension than the steady flow of a certain increase (P lt;0.05), compared with suspension nanoemulsion has greatly improved the steady-state flow (P lt;0.01). that nanoem