Natural Anthraquinone Mechanisms of anti-tumor effect.doc

 PAGE \* MERGEFORMAT 12 Natural Anthraquinone Mechanisms of anti-tumor effect [Keywords:] anthraquinone; antineoplastic agents, plant type; plants, medicinal Through a variety of traditional Chinese medicine active ingredients of anti-cancer screening was found, rhubarb, madder, and aloe vera has anti-tumor activity of traditional Chinese medicine ingredients, such medicine is a major nucleus anthraquinone compounds such as emodin, rhein and aloe-emodin, etc. . now commonly used in clinical anticancer drug doxorubicin and mitoxantrone is also the basic nucleus anthraquinone structure, suggesting that the mother has a core structure of anthraquinone compounds that have anti-tumor activity. An anti-tumor anthraquinones 1.1 Emodin Emodin is a natural anthraquinone pigment, is commonly used in Chinese herbal medicine rhubarb, Polygonum cuspidatum, aloe vera, cassia seed, and fleece-flower root, etc. One of the main active ingredient, the chemical known as 1,3,8 - trihydroxy -6 - methyl - Anthraquinone (1,3,8-trihydroxy-6-methylanthraquinone). 1.2 Rhein Rhein (Rhein ,4,5-dihydroxyan-thraquinone, RH) is a single-core type anthracene 1,8 - dihydroxy anthraquinone derivatives from rhubarb, fleece-flower root and other herbs of Polygonum cuspidatum separation and purification. 1.3 anthracene derivatives of anthracene derivatives are widely distributed in the plant kingdom of the pigment is a mixture of the active ingredients of Chinese herbal medicine. It is reported that isolated from the aloe vera extract a highly efficient anti-tumor effect of anthracene derivatives, including hydroxy-anthraquinone derivatives animals and anthralin derivatives [1]. Mengyun, etc. [2] reported that Aloe contains six kinds of anthraquinone compounds, namely, aloe emodin, emodin, chrysophanol, emodin, rhein and 1, 8 - dihydroxy -9,10 - anthrone -3 - methyl - (2 - hydroxy) propionate. 2 of natural anthraquinones in the mechanism of anti-tumor effect 2.1-induced apoptosis of tumor