Nanoparticles prepared by double emulsion of Saussurea.doc

 PAGE \* MERGEFORMAT 12 Nanoparticles prepared by double emulsion of Saussurea Of: Zhao Xinyi, Shen Qi, Liming Li, Jia Xiaoguang, Bola Ti Maccabi force [Abstract] Objective Xuelian injection intermediates as raw material, preparation of nanoparticles snow lotus, Saussurea medication to improve patient compliance and achieve sustained action. Methods emulsion nanoparticles prepared lotus, Saussurea drug substance dissolved in ethylene alcohol as internal water phase, polylactic acid polyglycolic acid copolymer (PLGA) dissolved in dichloromethane - acetone (2:1) mixed solvent as the oil phase, adding emulsifiers to form W / O type of colostrum with distilled water after role as the external phase in the emulsion formed under W / O / W type double emulsion nanoparticles solution. Results The average diameter of nanoparticles 134 nm; Zeta potential of -8.06; encapsulation efficiency was 42.83%, drug loading was 2.17 %; 12 h in vitro release of 39.57%. Conclusion double emulsion can be stable and function of the snow lotus has a slow release nanoparticles. [Keywords:] medusa; PLGA nanoparticles; double emulsion; release Abstract: ObjectiveTo prepare saussurea nanoparticles by using of saussurea injection intermediate so to improve the patients’ compliance and release slowly. MethodsMultiple emulsion method was used to prepare the saussurea nanoparticles. Saussurea injection intermediate dissolved in ethylene glycol as internal water phase, PLGA dissolved into the mixed solution that dichloromethane: acetone was 2:1 as oil phase, adding emulsifier to form W / O type primal emulsion, then add the primal emulsion to the distilled water contain emulsifier to form W / O / W type multiple emulsion. ResultsThe particles mean size of the best prescription of the nanoparticles was 134 nm, the drug loading was 42.83%, and encapsulation ratio was 16.08%. Vitro release rate was 39.57% in 12 hours. ConclusionThe stable and slow-released saussurea nanoparticles can be