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Myricetin tablet on experimental cerebral ischemia and its effects on thrombosis
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Myricetin tablet on experimental cerebral ischemia and its effects on thrombosis
Authors: QIN Jie-ping, WANG Nai-ping, ZHONG Zheng-Xian, Chen Xue-fen, Li Yan Jing, Zhang Wei
[Abstract] Objective To study the myricetin tablet on experimental cerebral ischemia and the protective mechanisms of thrombus formation. Methods bilateral carotid artery ligation in rats prepared by experimental cerebral ischemia-reperfusion injury model by measuring brain water content, superoxide dismutase (SOD), monoamine oxidase (MAO) activity and malondialdehyde (MDA), lactate (LA) levels were observed Myricetin tablet on experimental cerebral ischemia; venous thrombosis in vivo method used to observe the myricetin tablet venous thrombosis in vivo effects; and to study their the effects on platelet aggregation. Results Compared with model group, myricetin tablet each dose group (140,70,35 mg / kg) could significantly improve brain edema, reducing formation of lipid peroxidation, reducing lactic acid accumulation, and inhibit monoamine oxidase ; significantly reduce the weight of venous thrombosis in rats; significantly inhibited ADP-induced platelet aggregation. Conclusion Myricetin tablet in rats with acute cerebral ischemia in a clear protective effect, and antithrombotic significant role in the mechanism may be related to inhibition of lipid peroxide damage and enhance antioxidant enzyme activity, to improve the coagulation status, inhibiting platelet dependent of thrombus formation.
[Keywords:] Myricetin dispersible tablets; experimental cerebral ischemia; thrombosis; platelet aggregation
Abstract: ObjectiveTo investigate the effect of Myricetin Dispersible Tablets on experimental cerebral ischemia-reperfusion injury in rats and thrombosis formation.MethodsExperimental cerebral ischemia-reperfusion injury model was induced by ligation bilateral common carotid arteries. The protective effect of myricetin dispersible tablets was observed by detecting the
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