Natural biological scaffold material in cartilage repair of Research Progress.doc

 PAGE \* MERGEFORMAT 24 Natural biological scaffold material in cartilage repair of Research Progress Author: Sun Tianwei, Kongqing Quan, Yang Zhiming [Keywords:] cartilage repair The lack of regeneration of articular cartilage, trauma or disease caused by cartilage defects using cartilage or other materials required to repair. Limited sources of autogenous cartilage, and likely to cause donor site defects, the application is restricted. Allogeneic cartilage has been widely applied, but can cause immune rejection response, which led to cell death and loss of function. Periosteal transplantation had a passing fad, but there is instability in long-term effects of defects, enabling people to constantly explore better repair method. The success of in vitro cultured cartilage cells, triggering the people trying to direct use of cartilage cells to repair cartilage defects. In 1968, Chertman such as the cartilage cell suspension injected into the articular cartilage defect site, results showed that: defects of synovial fibroblasts in tissue repair, microscope only see a small amount of new cartilage cells in nodules. In 1977, Green and so on in order to demineralized bone as a stent, and inoculation on the cartilage cells, transplanted into the defect site. Although not successful, gratifying the first time the author: If able to find a suitable scaffold material, the cartilage cells were seeded thereon, that it is possible to form a good cartilage tissue repair. At present, the development of tissue engineering scaffolds for cell culture bio-scaffold materials can be divided into two categories, namely natural biological scaffold material and the synthetic scaffold. Natural biological scaffold material with a cellular signal recognition, promote cell adhesion, proliferation and differentiation, good biocompatibility and good biodegradability, etc., show that synthetic scaffold incomparable advantages. In this paper, the natural scaffold material in cartilage repai