Neoadjuvant chemotherapy in the treatment of different osteosarcoma clinical observation.doc

 PAGE \* MERGEFORMAT 16 Neoadjuvant chemotherapy in the treatment of different osteosarcoma clinical observation Of: in the show soon, Xu Ming, Wang Wei, Song, if the first [Abstract] [Objective] To investigate the different chemotherapy regimens on the efficacy of the treatment of osteosarcoma. [Methods] Retrospective analysis of 40 cases of this institution Ⅱ B treatment of osteosarcoma. 18 males and 22 females, aged from 5 to 40 years, mean 16 years of age, the incidence areas: the distal femur in 19 cases, proximal tibia in 13 cases, proximal humerus in 3 cases, proximal femur, 2 cases of femoral shaft in 2 cases, upper end of fibula in 1. random application MMIA programs in 17 cases, DIA program 23. treatment definitive diagnosis for the biopsy underwent 2 courses of chemotherapy before surgery, rest for 2 weeks after surgery, 6 courses of chemotherapy after surgery to continue. [Results] 40 patients were followed for an average 58 months. follow-up period 14 patients died, the other 3 cases of lung metastases, with survival is local recurrence in 5 cases. The comparative analysis of different chemotherapy regimens with chemotherapy, the tumor cell necrosis rate, the incidence of adverse reactions was no correlation. MMIA program 5-year disease-free survival was 41.18%, DIA program for the 5-year disease-free survival 48.70%, no significant differences between the two. [Conclusion] MMIA programs and DIA osteosarcoma treatment programs no significant difference in efficacy, in view of the clinical application of DDP has better treatment compliance . So DIA program can be used as the first choice of conventional osteosarcoma chemotherapy. [Keywords:] osteosarcoma, neoadjuvant chemotherapy, chemotherapy regimen, compared Abstract: [Objective] To study the clinical results of different neoadjuvant chemotherapy protocols in the treatment of osteosarcoma. [Method] Forty patients with IIB osteosarcoma, 18 males and 22 females with the mean age of 16 y