Nervous system neurotensin.doc

 PAGE \* MERGEFORMAT 22 Nervous system neurotensin [Keywords:] nervous system neurotensin Neurotensin (Neurotensin, NT) 1973 was first extracted from bovine hypothalamus, is a kind of Biological activity of single-chain polypeptide, was later found to NT also present in human and other mammals, the gastrointestinal tract and other organizations , Such as the adrenal medulla, thyroid and so on. As a brain-gut peptide, NT has a neurotransmitter, neuromodulator and the Bureau of The role of the Ministry of hormones. In this paper, its chemical characteristics, distribution, receptors, biological effects and their role in the nervous system machine The production of a review. 1NT release of the chemical nature and synthesis In 1973, Carraway et al [1] In the separation of substance P hypothalamus of cattle (Sub ˉ stanceP, SP) And found a new peptide, can cause blood vessels in anesthetized rats exposed to a remarkable expansion of the skin, because from the nervous system With a reduced role of vascular tone, so named neurotensin (Neurotensin, NT). 1975 Some scholars [2] using Merrifield solid phase synthesis of the first time, NT, confirmed that the 13 amino acid residues from the group of Cheng, molecular weight is 1673. N-terminal of the lack of free-NH2, C-terminal may be carboxypeptidase (Carboxypeptidas e) hydrolysis, which ranked in the following order: coke Valley - bright - casein - Valley - Door acyl - Lai - Preserved - Precision - Precision - Pro - Tyr - Ile - bright-OH . NT molecules after the 6 amino acid residues with all of its biological activity, that is, NT (8-13) (refined 8 - Fine 9 -- Preserved 10 - Tyr 11 - Ile 12 - Liang 13), but the NT (8-13) are not produced in the body drop NT One solution fragments. NT molecules to a change in amino acids, synthetic NT (8-13) analogues with Eisai compound Materials [3], NT64L, NT66L, NT67L and NT69L, both through the blood - brain barrier. In 1987, DobnerPR, etc. [4] succes