Neuronavigation assisted transsphenoidal microsurgical removal of large invasive pituitary adenoma.doc

 PAGE \* MERGEFORMAT 12 Neuronavigation assisted transsphenoidal microsurgical removal of large invasive pituitary adenoma Of: Zhang Guoliang, Yang Weizhong, Dan Songsheng, Renbao Gang, Chen Zhen [Abstract] Objective transsphenoidal removal of large invasive pituitary adenoma. Methods Retrospective analysis of neuronavigation assisted by a single nostril transsphenoidal microsurgical treatment of 37 patients with large invasive pituitary adenomas clinical data. Results of neuronavigation-assisted resection of tumor in 18 cases, subtotal resection in 12 cases, subtotal in 6 cases, 1 case of postoperative death. Conclusion of neuronavigation-assisted transsphenoidal removal of large invasive pituitary adenomas trauma, the relative safety and fewer complications, a large invasive pituitary adenomas as the main means of treatment. [Keywords:] Pituitary tumors, adenomas, sphenoid sinus, neural navigation, microsurgery Invasive pituitary adenomas has its own biological characteristics, the growth of tumor cells more active. Were often no obvious symptoms and signs of early, when treatment has been developed for large multi-or macroadenoma adenomas, and violations of the surrounding structures such as dura mater, bone, cavernous sinus, hypothalamus and the important nerves and blood vessels, this time more than pituitary endocrine function was affected, surgical resection with considerable difficulty and risk [1]. With the advances in microsurgical technique, and neurological surgeons of transsphenoidal of experience, most of these pituitary adenoma transsphenoidal be the preferred treatment. I Hospital from October 2002 -2006 adopted on December neuronavigation-assisted transsphenoidal removal of large invasive pituitary adenoma in 37 cases, satisfactory results are summarized as follows. 1 Clinical data 1.1 General information of 37 patients, 21 males, 16 females, age (40.8 + -18.9) years (17 to 69 years), tumor recurrence, 6 cases re-operation. Du