Neurotrophin receptor p75NTR at different gestational age human fetal hippocampus in the expression of.doc

 PAGE \* MERGEFORMAT 5 Neurotrophin receptor p75NTR at different gestational age human fetal hippocampus in the expression of Author: Wang with blue, HU Yu-hui, LIAO Yi-Lin, Peng Jianan, Wen Yongshun [Keywords:] neurotrophin receptor; hippocampus; human fetal brain [Keywords:] neurotrophin receptor; hippocampus; human fetal brain 0 Introduction Neurotrophin is a highly conserved growth factor family, including two kinds of receptors: low affinity neurotrophin receptor p75 (p75 neurotrophin receptor, p75NTR) and high-affinity Trk. P75NTR is a Mr 75 000 and I-type membrane protein belonging to tumor necrosis factor receptor superfamily (TNFR Ⅰ ) members. p75NTR in different conditions to play a completely different biological effects, on the one hand, when co-expression with Trk, a combination of both into a hybrid dimer, the formation of neurotrophic factor in the high-affinity receptor for nerve cell survival and growth; the other hand, when the expression of p75NTR alone when it all with the same affinity neurotrophic factor binding and the induction of apoptosis [1 -- 2]. hippocampus is the limbic system, and learning and memory, emotional, behavioral and visceral activities closely related to the development of the hippocampus during the embryonic neural cell proliferation, differentiation and apoptosis in activity. Our research p75NTR in the embryonic development of the hippocampus in the process of changes of expression and to explore the development of neurons in p75NTR impact. 1 Materials and methods 1.1 Material collected 45 cases of clinical cystic induction of fetal (gender not limited to), by the end of sub-periods of time with measuring crown-rump length (Patten method [3]) projection gestational age, according to gestational age were divided into 13 ~ 16 wk (n = 10), 17 ~ 20 wk (n = 12), 21 ~ 24 wk (n = 9), 25 ~ 28 wk (n = 8), 29 ~ 32 wk (n = 6) 5 group. Each fetus had no cases of cystic induction of labor nervous system malformations, and h