New Zealand acute radiation otitis media with effusion and study of rabbit model.doc

 PAGE \* MERGEFORMAT 15 New Zealand acute radiation otitis media with effusion and study of rabbit model Of: Zhang Xin Mao Yonglin steel contact Chan Ching Liu Xiang Zheng billion [Abstract] [Objective] To establish acute radiation otitis media with effusion in New Zealand rabbit model, and the effects of different radiation dose, way of the middle ear. [Method] 72 healthy New Zealand rabbits were randomly divided into 4 groups (n = 18) , including the control group (A group) and three experimental groups B, C, D. B group applied radiation dose of 30 Gy / second 1 time, C group was 10 Gy / times 3 times, D group was 10 Gy / time 6 times. In the light before and after irradiation, 1 day, 1,2,4,8,12 week endoscopy were performed ear, middle ear CT, acoustic impedance check, and after radiotherapy for each observation time point each group were killed 3 rabbits, whichever nasopharyngeal mucosa, listening to bubble histological examination. [results] initially established acute radiation otitis media with effusion in New Zealand rabbit model. [Conclusion] establish radioactive rabbit secretory otitis media animal model is feasible, but a single large dose of ionizing radiation is the key to a successful modeling. [Keywords:] radiation; secretory otitis media; animal model Abstract: [Objective] To establish a model of radiological secretory otitis media using New Zealand rabbits, and to observe the results of different radiation dosages and modalities. [Methods] Seventy-two healthy New Zealand rabbits were randomly divided into four groups (18 for each), including one control group named group A, and three experimental groups named group B, C and D. Group B was administered with a radiation dose of 30 Gy per for once, while group C with 10 Gy per for three times and group D with 10 Gy per for six times. Before given the radiation and on the 1st day, 1st week, 2nd week, 4th week, 8th week and 12th week after, endotoscopy was carried out respectively as