NF-κB and its relationship with the biological characteristics of the relationship between liver disease.doc

 PAGE \* MERGEFORMAT 14 NF-κB and its relationship with the biological characteristics of the relationship between liver disease Keywords: NF-κB cell factor liver disease NF-κB is a widely present in the body cells, nuclear transcription factor, regulating cytokines, chemokines, growth factors, adhesion molecules, immune receptor gene expression, affecting the body’s cell differentiation, immune response, inflammatory response , apoptosis, tumor growth and other biological functions. Studies have shown that NF-κB signaling pathway over-activation of human diseases closely related, so by the scientific community attention. 1 NF-κB in the structure and function of NF-κBNamely, nuclear factor -kappa B(nuclear factor dappa B, NF-κB) Is1986BySenAndBaltimoreThe regulation of the first identified in miceBLymphocytes found in a can and immunoglobulin κ light chain gene enhancerB site-specific integration of nuclear protein factor, later discovered that is widely found in various types of cells, nuclear transcription factor, it will be named nuclear factor-κB (nuclear factor dappaB) [1]. As a quick reflection transcription factor involved in a variety of cytokines, chemokines, growth factors, adhesion factors, oxidative stress-related gene expression of enzymes is now clear that, in the occurrence and development of sepsis, NF - κB is a LPS-channel signal transduction pathway hubs, play a central role. 1.1 NF-κB family structure and function of NF-κB family, a total of five members, and they are RelA (p65), RelB, c-Rel, P50 and P52. All of the above members have an N-terminal 300 amino acids from the Rel homology domain (rel homology domain, RHD) containing the DNA binding domain, dimerization domain and nuclear localization signal area (nuclear translocation signal, NLS) , respectively, has the DNA sequence of the κB motif (κBmotif) combined with homologous or heterologous subunits form a dimer, and NF-κB inhibitory protei