Nuclear transcription factor-κ B in lung inflammatory diseases the role of.doc

 PAGE \* MERGEFORMAT 11 Nuclear transcription factor-κ B in lung inflammatory diseases the role of [Keywords:] transcription factor; inflammation; lung Acute and chronic pulmonary, bronchitis lung disease is that many diseases such as asthma, chronic obstructive pulmonary disease, adult respiratory distress syndrome and idiopathic pulmonary fibrosis, a common pathological changes. These diseases, and characteristics of different sites of inflammation, However, the lungs were clear inflammatory cell infiltration and activation of immune cells, while activated cells can secrete some of the important role played by inflammation cytokines, oxidants, and many inflammatory mediators [1]. In recent years, results showed that airway epithelial cell is an immune effector cells to secrete pro-inflammatory factor, oxidants and cytokines [2], while the persistence of inflammation in the lung would be damaging. there are a number of factors currently considered a special area with the gene combination to improve the transcription of specific genes , which are mostly concentrated in special regions of the upstream gene promoter. These factors are mostly steroid can be transduced to the nucleus, and the specificity of nucleic acid sequences on the combination of increased gene transcription, thereby increasing mRNA expression and inflammatory factors generation, and inflammation-related transcription factors are mainly nuclear transcription factor-κ B (NF-κ B) and activator protein 1 (AP-1) [3], others are activated T cell nuclear factor, glucocorticoid receptor, cAMP response element binding protein, GATA transcription factor, E26 transcription factor and signal transducer and activator of transcription family of transcription factors and other agents. in lung inflammation in the transcription factor gene promoter with the appropriate combination of binding sites [4]. mastered transcription factor function and its mechanism of transcriptional regulation will be the resea