Nucleus accumbens and ventral tegmental area in drug-induced destruction of morphine drug-seeking behavior.doc

 PAGE \* MERGEFORMAT 8 Nucleus accumbens and ventral tegmental area in drug-induced destruction of morphine drug-seeking behavior [Keywords:] morphine Lesion effects of nucleus accumbens and ventral tegmental area on drug priminginduced reactivation of extinguished conditioned place preference in rats [Abstract] AIM: To examine the possible role of nucleus accumbens (NAc) and ventral tegmental area (VTA) in drug priminginduced reactivation of extinguished conditioned place preference (CPP). METHODS: After the rats were successfully trained with morphine (10 mg / kg, sc.) by a CPP paradigm, NAc and VTA were lesioned with a DC current passing through the location. After a 15day abstinence period, drug priming (morphine 1 mg / kg, sc.) was given and the place preference score was recorded. RESULTS: Drug priming reactivated the place preference in sham lesion rats. However, the effect of drug priminginduced reactivation of extinguished CPP could be completely abolished by lesion of NAc and VTA. CONCLUSION: These results indicate that NAc and VTA play an important role in drug priminginduced reactivation of extinguished CPP. [Keywords] morphine; relapse; nucleus accumbens; ventral tegmental area; conditioned place preference [Abstract] Objective: To study the directed destruction of the nucleus accumbens (nucleus accumbens, NAc) and ventral tegmental area (ventral tegmental area, VTA) in drug-induced abstinence of morphine drug-seeking behavior, analysis NAc and VTA in the Great addictive behavior in rats. Methods: Male SD rats were enhanced by the formation of morphine-conditioned place preference, use the DC were destroyed after the NAc and VTA.15 d given sc morphine-induced place preference behavior in rats restored, measure and compare the damage group and the control group place preference score. Results: NAc and VTA damage group and the destruction of rats induced by the injection of morphine did not restore morphine conditioned place preference [NAc dama