Nucleoside analogue therapy clinical study of chronic hepatitis B.doc

 PAGE \* MERGEFORMAT 6 Nucleoside analogue therapy clinical study of chronic hepatitis B 【Abstract】 Objective To investigate the nucleoside-type drugs with chronic hepatitis B, the existing and the prevention and control measures. Lamivudine (Lamivudine, Lamivudine) Adefovir (A very Fauver), Entecavir (Baraclude), Telbivudine (telbivudine for) four kinds of object-nucleoside class medicine clinical efficacy as well as the treatment of chronic hepatitis B HBV may occur in genetic variation, raised on how the rational use of nucleoside drugs, how to reduce the HBV genetic variability and countermeasures. The results of clinical application of nucleoside drugs with rapid reduction of hepatitis B virus load, improve liver histology lesions, to promote recovery of liver function, clinical indications should be strictly controlled, regular medical follow-up, for possible genetic variation of HBV cases, the need for timely replacement of antiviral drugs. Conclusion Chronic Hepatitis B anti-viral treatment is an important part of nucleoside analogue drugs are effective treatment of chronic hepatitis B antiviral drugs. Keywords: chronic hepatitis B; nucleoside drugs; clinical application Is generally believed that hepatitis B virus (CHB) disease in itself is limited, the body’s immune function (mainly cell-mediated immunity) in the removal process of the virus causing the immune pathological damage, leading to liver cell lesions, necrosis, there was a series of clinical symptoms and serological abnormalities, but in the disease and in the course of antiviral drugs can be rid of the virus and human immunodeficiency virus is found the level of relevance. Rehabilitation, the first decline in a virus, and then experience clinical remission; relapse, then the first increase in the level of a virus, and then exacerbations. This shows that the virus as a target antigen immune response in determining the course of development of the disease played an impor