Obstructive sleep apnea syndrome and stroke analysis of the relationship between progress in.docVIP

 PAGE \* MERGEFORMAT 10 Obstructive sleep apnea syndrome and stroke analysis of the relationship between progress in [Keywords:] Obstructive sleep apnea syndrome an independent risk factor for stroke Sleep apnea and stroke in patients with very high complication rate, OSAS before in the stroke may also occur after stroke, reciprocal causation between the two, has a complex interaction mechanism. Therefore, OSAS and brain understanding of the relationship between stroke for stroke treatment and prevention are important. 1 Obstructive sleep apnea syndrome is an independent risk factor for stroke OSAS for stroke is an independent risk factor for sleep prone to ischemic stroke, OSAS patients with stroke risk was 3.75 (95% CI, 1.52 ~ 7.59), incidence of 10.3 times the non-OSAS patients (95 % CI, 3.5 ~ 30.1), OSAS lead to stroke occurrence and development of possible mechanisms of sleep apnea, the frequency of airway obstruction can lead to hypoxemia, hypercapnia, chest negative pressure and repeated awakening, which led to sympathetic activation, hemodynamics, coagulation abnormalities and vascular injury [1]. Tsukamoto et al [2] found that, OSAS in apnea can increase the activity of protein -1 (activator protein-1, AP-1) and hypoxia inducible factor -1 (hypoxia-inducible factor-1, HIF-1) transcriptional activity, causing vascular endothelial growth factor (vessel endodermis growth factor, VEGF) expression, leading to regeneration of new blood vessels after cerebral ischemia. And after the end of the apnea, there will be high ventilation, increased sympathetic tone, catecholamines and renin - angiotensin system and nitric oxide synthase reduced regulation, reactive oxygen species can mediate the production of angiotensin Ⅱ in the vascular remodeling plays a key role. long-term repeated hypoxia and reoxygenation lead to vascular smooth muscle proliferation, and proliferation of arterial smooth muscle of the middle, hypertrophy, migration to the intima,