Of acute organophosphorus pesticide poisoning and first aid care.docVIP

 PAGE \* MERGEFORMAT 10 Of acute organophosphorus pesticide poisoning and first aid care One. Overview Organophosphorus pesticides are mostly organic phosphate lipid compounds, through the skin, respiratory and digestive tract into the human body, combined with the in vivo AChE choline phosphate to form a more stable enzyme lost its ability to break down acetylcholine, causing acetylcholine in large accumulation of the body, resulting in over-excited nerve function, and then transferred to suppression, there was a series muscarinic, nicotinic and central nervous system signs and symptoms of poisoning. a history of exposure to toxic substances, the typical clinical presentation and whole blood cholinesterase decline in activity is the main basis for diagnosis. Treatment includes elimination of toxins, early enough and repeated atropine and cholinesterase agents, prevention and complications. II. Clinical manifestations 1. Muscarinic symptoms: sweating, salivation, tearing, runny nose, increased respiratory secretions, pulmonary rales, chest tightness, bronchospasm, pulmonary edema, respiratory difficulties, nausea, vomiting, loss of appetite, abdominal pain, bowel Music hyperactivity, diarrhea, fecal incontinence, urinary frequency, urinary incontinence, eye pain, blurred vision, blurred vision, miosis, bradycardia, hypotension. 2. Nicotine-like symptoms: pale skin, rapid heartbeat, muscle bundle trembling, weakness, muscle cramps, muscle paralysis, respiratory muscle paralysis. 3. Central nervous system symptoms: headache, dizziness, malaise, fatigue, insomnia or sleepiness, irritability, confusion, confused speech, delirium, convulsions, coma, respiratory arrest caused by inhibition of the respiratory center. 4. Intermediate syndrome of acute poisoning in a few cases and after relief of symptoms before the occurrence of delayed neuropathy (acute poisoning, 24 ~ 96 hours) sudden difficulty in breathing or death, cal