Of basic fibroblast growth factor in prostate cancer and benign prostatic hyperplasia tissues significance of.doc

 PAGE \* MERGEFORMAT 12 Of basic fibroblast growth factor in prostate cancer and benign prostatic hyperplasia tissues significance of Author: Yan-Bo Liu, Shen-dimensional high-Zhao Jian [Abstract] Objective To study the basic fibroblast growth factor (bFGF) in prostate cancer and benign prostatic hyperplasia tissues significance. Methods dot-blot hybridization and immunohistochemical determination of 50 cases of normal prostate tissue (normal control group), 40 patients with benign prostatic hyperplasia (BPH) organizations and 48 cases of prostate cancer the expression of bFGF. The results of BPH and prostate cancer tissues the expression of bFGF was significantly higher than the normal control group (P amp;lt;0  01). bFGF expression was elevated in the sub-degree and degree of BPH and prostate cancer, the relationship between pathological grade and clinical stage was not significant. Conclusions bFGF with prostate cancer and benign prostatic hyperplasia in the occurrence and development processes. [Keywords:] prostatic hyperplasia; prostate cancer; basic fibroblast growth factor (bFGF) Prostate cancer and benign prostatic hyperplasia is a common disease in elderly men. In recent years, research data shows that prostate cancer and benign prostatic hyperplasia tissues there are many abnormal expression of molecules, but its pathogenesis is still a lack of a unified understanding of 〔 1,2〕 . Basic fibroblast growth factor (basic fibroblast growth factor, bFGF) is a common endothelial cell mitogen, through autocrine or paracrine mechanism to promote angiogenesis, tissue regeneration, inhibit cell apoptosis and enhanced cell invasion ability with many diseases closely related to the occurrence and development. The results showed that bFGF in prostate cancer and benign prostatic hyperplasia in the pathogenesis also play an important role in 3 ~ 7〕 〔 . We use dot-blot hybridization and immunohistochemical staining methods, bFGF observed in normal prostate, ben