Of blood and blood components of bacterial contamination Present Situation and Countermeasures.doc

 PAGE \* MERGEFORMAT 20 Of blood and blood components of bacterial contamination Present Situation and Countermeasures A bacterial contamination of blood and blood components status Since 1941, the United States reported the importation of bacterial contamination of blood components and death. After the transfusion of such incidents continue to occur. The 20th century, 80’s, stored at room temperature under the conditions of bacterial contamination of platelet coverage has also increased. Despite the improved sterile blood collection technology, but the pollution caused by bacteremia blood components remains at a fixed rate, and in fatal cases have occurred from time to time [1]. Transfusion-transmitted HBV, HCV and HIV, respectively, the proportion of 1 / 20 million, 1 / 6000 ~ 1 / 10 million and 1 / 45 million to 1 / 60 million, due to detection reagents and improvements in technology, the more blood-transfusion-transmitted diseases, pollution, The incidence has declined markedly. Therefore, bacterial contamination of blood has recently drawn increasing attention [2]. September 25, 1995 FDA and the AABB and other NIH Clinical Center in the United States initiated the convening of a “status of microbial contamination of blood components” seminar. The purpose is to review the causes of bacterial contamination of blood components, measurement, and prevention [3]. FDA stressed that all practicing certificate holders and registered manufacturers, as well as blood transfusion institutions are required to 7d of the FDA’s inspection and supervision departments within the report and transfusion-related deaths. FDA reports deaths each year compared with 30 to 50 cases, of which nine cases of bacterial contamination of [3]. Ramsey et al [4] reported that since January 1993 ~ December 1996 the U.S. blood components strong FDA inspection reports, 960 were in the blood, bacterial contamination accounted for 0.2%. Klein et al [3] pointed out that