Of octreotide on acute necrotizing pancreatitis-associated lung injury in rats.doc

 PAGE \* MERGEFORMAT 13 Of octreotide on acute necrotizing pancreatitis-associated lung injury in rats 【Abstract】 Objective To observe the effects of octreotide on acute necrotizing pancreatitis (acute necrotizc pancreatitis, ANP) in rat lung injury in rats and to explore its mechanism. Methods The rats were 63, in the pancreatic duct injection of 5% sodium taurocholate-induced rat model of ANP. Observe the effects of octreotide on ANP in rat lung tissue morphology and cytokine changes. Results Octreotide treatment group compared with ANP NS group of lung wet / dry weight significantly reduced, PaO2 significantly increased BALF protein content [Octreotide group (339.9 ± 72.5) mg / L], and white blood cell count decreased or showed a downward trend. Meanwhile, the plasma endotoxin, serum levels of TNFα and NO2-/NO3- lung tissue NOS activity was significantly decreased pulmonary vascular endothelial cells and duct epithelial cells of nitric oxide synthase (NOS) expression of reduced lung histopathological changes to reduce. Conclusion of octreotide on pulmonary injury in rats with ANP have a certain therapeutic effect, its mechanism and its endotoxin, tumor necrosis factor-α and nitric oxide in the regulation of inflammatory mediators such as related to the role. Beneficial effects of octreotide on the lung injury following experimental acute necrotic pancreatitis in rats 【Abstract】 Objective To investigate the possible beneficial effects of octreotide on the lung injury following acute necrotizing pancreatitis (ANP) and the mechanisms.Methods The ANP model of rat was established by injection of 5% sodium taurocholate into the choledochus.Results Octreotide could decrease Wet / dry lung ratio significantly at all indicated time-point. At 12th h after induction of ANP, PaO2, protein content in BALF, plasma endotoxin level, serum NO2-/NO2-, and NOS activity were much lower in octreotide-treated rats than those in untreated group (P lt;0.0