Of vitamin E on noise induced cochlear hair cells in the regulation of expression of NF-κ B.docVIP

 PAGE \* MERGEFORMAT 2 Of vitamin E on noise induced cochlear hair cells in the regulation of expression of NF-κ B [Abstract] Objective To investigate the vitamin E in the noise exposure causes hearing impairment in rats has obvious protective effect and its mechanism. Approach to hearing thresholds, cochlear basement membrane stretched and immunofluorescence staining as an indicator to observe the rats exposed to continuous noise in the steady-state before the 30 days to 7 days after exposure, vitamin E or saline irrigation on the rat auditory brainstem response analysis and cochlear outer hair cells (OHC) loss rate analysis and NF-κ B expression in the cochlear hair cell quantitative analysis. The results of vitamin E in rats after the noise exposure hearing threshold was significantly lower than the noise alone group, OHC loss rate is also significantly reduced immunofluorescence staining showed that the intervention group of the cochlea VitE cells expressed NF-κ B than the intensity of the noise alone group (P amp;quot;0.05). Conclusion of vitamin E in the noise exposure causes hearing impairment in rats has obvious protective effect on cochlear hair cells by upregulating NF-κ B expression. [Keywords:] noise; cochlea; hair cells; vitamin E; NF-κ B [Abstract] Objective To discuss the protection and mechanism of vitamin E in the rats hearing impairment induced by noise exposure.Methods Take the audibility threshold, basilar membrane stretched preparation and immunofluorescence stain as the index, observing that the rats were put in the stationary noise before 30days until after that for 7days, have vitamin E and sodium chloride, check the auditory brain stem potential and the lost rate and NF-κ B of the OHC in the cochlea hair cells expression quantitative analysis.Results After the noise exposure, the rats which have vitamin E have significant lower auditory acuity threshold than the purely noise exposure, and much lower lost rate of OHC.Immunofluorescenc