On drug induced serious adverse interactions.docVIP

 PAGE \* MERGEFORMAT 8 On drug induced serious adverse interactions [Keywords:] adverse drug interactions Drug interactions caused serious adverse reactions, should arouse our attention, without attention, can lead to dire consequences. A hypertensive crisis Monoamine oxidase inhibitors (such as glibenclamide, furazolidone, etc.) and ephedrine, metaraminol, methylphenidate, tyramine and other combination, can noradrenaline release from the storage site a large number of hypertensive crisis occurs, and death . monoamine oxidase inhibitors and tricyclic antidepressants, levodopa combination also cited hypertensive crisis. According to reports, 15 cases of hypertensive crisis, of which 6 patients were treated with tricyclic antidepressants after the dental local anesthesia, local anesthetic solution containing 0.4 ms / rIll caused by norepinephrine, therefore, application of tricyclic antidepressants, the local anesthetic solution should not be added in the norepinephrine and vasoconstrictor. guanethidine, benzyl a clear (Bethanidine), debrisoquine (Dbris-aguine) and other anti-hypertensive drugs could be uptake by the amine pump and into adrenergic nerve endings of the vesicles, thereby preventing the release of neurotransmitters. the blood pressure. III Central class of depression drugs can inhibit the adrenergic nerve endings in the membrane amine pump, prevent intake of these drugs is peripheral, thus making it so they can not play a role in blood pressure, blood pressure can increase rapidly. 2 severe hypotension Chlorpromazine not with hydrochlorothiazide, furosemide and uric acid combined with the interest, which all have the antihypertensive effect of diuretics, chlorpromazine significantly increased the blood pressure response to howl, causing severe hypotension. Propranolol and chlorpromazine should not be or a combination of prazosin. propranolol can block β-adrenergic receptor, while chlorpromazine and prazosin block a receptor in th