On the apparent genetic epidemiology.docVIP

 PAGE \* MERGEFORMAT 23 On the apparent genetic epidemiology [Keywords:] the apparent genetic epidemiology First, the apparent genetic and epigenetic epidemiology Recent studies show that the genetic information of higher complexity of life, not only the structure of the genome has more genes encoding proteins, but also in gene expression regulation mechanism of the complex. Thus gene expression is the core of modern molecular biology. The main study without change the DNA sequence changes in gene expression under the conditions, this change can not only affect the individual’s development, but also can be hereditary, so epigenetics (epigenetics) came into being. epigenetic DNA sequence is not changed, and gene expression of the genetic changes that can occur [1]. epigenetic change from 3 regulation of gene expression levels [2] 1.DNA Modified: DNA covalent binding of a modified group, for example, methyl group (CH3), so has the same sequence of alleles in different modification states; 2. Histone modification: protein modification or by changing the conformation of proteins to regulate gene expression, for example, histone acetylation, etc.; 3. Non-coding RNA regulation: the non-coding RNA gene transcription by some mechanism or post-transcriptional regulation and control, such as RNA interference (RNA interference, RNAi). Epigenetics of the content is very extensive, involving chromatin remodeling, DNA methylation, X chromosome inactivation and the regulation of non-coding RNA [2], the present study the most adequate epigenetic change is DNA methylation. Epigenetics by Feinberg [3] considered the center of modern medicine, it is because of its help to explain the individual’s genetic background, environmental factors, aging and disease relationships. Epigenetics to complete this Although the DNA sequence of the work because there is no change, but the epigenetic state of human life and different organizations are different, and as the