On the development and application of quinolones.docVIP

 PAGE \* MERGEFORMAT 10 On the development and application of quinolones [Paper Keywords] quinolone, development, and reasonable application of [Abstract] quinolones is a recently discovered a new class of synthetic antibacterial drugs. This paper describes the development of quinolones for over 40 years of history, and with reference to the domestic literature, describes the type of drugs in clinical applications and reasonable Some of the major considerations. these drugs is its unique and efficient disinfection and toxicity, and gradually established their dominance in the field of anti-bacterial. In recent years the rapid development of quinolone antibacterial drugs are a class of synthetic antibacterial drugs, has broad spectrum antimicrobial, antibacterial and strong, good oral absorption, tissue concentration is high, with no cross-resistance to other antimicrobial resistance, adverse reactions, etc., has become a clinical bacterial infections of the commonly used drugs. In 1962, U.S. Sterling-winthrop study found, the first containing 4-- quinolone nucleus of the drug - nalidixic acid, and other antibacterial drugs in their different roles in features, antimicrobial drug research and opened up new ways to use the .40 Over the years, the structure of quinolones at home and abroad continue to be modified, and to change its fluoride group, have developed a variety of new drugs into clinical use of these drugs gradually broaden the antimicrobial spectrum, from a single anti-Gram-negative narrow spectrum of bacterial strains, the development of anti-Gram-positive bacteria, anaerobic bacteria, Mycobacterium, Legionella, Mycoplasma and Chlamydia broad-spectrum antibiotics. The development of a promise TZDs 1.1 The first-generation drugs nalidixic acid, PPA, 1960 listing applications, only Gram-negative bacteria-induced urinary tract infections, pharmacokinetics and safety is not ideal, is already out of drugs. 1.2 The second-ge