On the expression of skin lymphoma and its clinical significance cyclinE.docVIP

 PAGE \* MERGEFORMAT 12 On the expression of skin lymphoma and its clinical significance cyclinE [Abstract] Objective: To investigate the cyclinE lymphoma in the skin and in tumor occurrence and development of the role. Methods: People’s Hospital of Wuhan University in 2006 and 2009 surgery and biopsy of the skin diagnosed by pathology lymphoma, 40 cases of paraffin, of which 22 cases of MF, 7 cutaneous anaplastic large cell lymphoma, 6 patients with other types of T-cell lymphoma, 5 cases of B-cell lymphoma. Another 20 cases of inflammatory skin lesions, including 10 silver debris disease, 10 cases, deputy psoriasis. immunohistochemistry tissues were observed in each group cyclinE expression. using HPIAS 2000 image analysis system cyclinE expressed in the above groups, the average optical density and the average rate of positive area. Results: cutaneous lymphoma was highly expressed in the cyclinE; cancer tissues showed low expression cyclinE. Image analysis showed: cutaneous lymphoma and inflammatory lesions of the skin between the average optical density and cyclinE positive area ratio of the difference was significant (P lt; 0.05). Conclusion: cyclin E is abnormally high expression to promote cell proliferation, and thus the pathogenesis of lymphoma in the skin play an important role. [Keywords:] cutaneous lymphoma; cyclinE; immunohistochemistry; image analysis Cutaneous lymphoma is one of skin cancer on the molecular biology of cutaneous lymphoma have shown that many genes and cytokines in the skin lymphoma to play an important role in the development process, the clinical significance can not be ignored [1,2]. Cell cycle is the accumulation of cellular material and cell division cycle, the orderly by the strict regulation and control. Cell proliferation is the infinity of the important characteristics of malignant tumors, which lead to cell cycle disorder is closely related to uncontrolled cell growth. Cyclin E is an important cell cycle regul