P16 cyclin kinase inhibitor expression in pterygium.doc

 PAGE \* MERGEFORMAT 7 P16 cyclin kinase inhibitor expression in pterygium [Abstract] Objective To investigate the pterygium tissue inhibitor of cyclin-dependent kinase expression of P16, to understand its role in the pathogenesis of pterygium. Methods of pterygium surgery and normal conjunctival tissue samples by immunohistochemistry method for cyclin-dependent kinase inhibitor P16 protein detection. Results of pterygium in the expression of the P16 (7.25 + -0.12%, while P16 expression in normal conjunctiva and (88.47 + -0.73%, the difference was very statistically significant (P lt;0.01, cell nuclear antigen (PCNA in normal conjunctiva and pterygium expression was (4.98 + -0.28% and (24.59 + -0.64% (P lt;0.01. Conclusion pterygium cyclin dependent kinase inhibitor P16 in the low expression may lead to pterygium cell cycle disorders, the proliferation of out of control. [Keywords:] pterygium, cyclin dependent kinase inhibitors, proliferating cell nuclear antigen [Abstract] Objective To observe the expression of cyclin kinase inhibitor P16 in pterygium and to investigate its effects on the pathogenesis of pterygium.Methods The normal conjunctiva tissues and pterygium were detected for cell circle related kinase inhibitor P16 with immunohistochemistry.Results The expression rates of P16 in conjunctiva and pterygium were (88.47 + -0.73% and (7.25 + -0.12%, there was significant difference between them (P lt;0.01.The expressions of PCNA in conjunctiva and pterygium were (4.98 + -0.28% and (24.59 + -0.64% (P lt;0.01.Conclusion The lower expression of cell circle related kinase inhibitor in pterygium may play an important role on proliferation and pathogenesis of pterygium. [Keywords:] pterygium, cyclin-dependent kinase inhibitor, PCNA Pterygium is a common eye disease, its pathogenesis is still unclear, especially whether the pterygium cell proliferation and cell cycle control disorder, there are studies [1] show that this disorder is dependent kinas