P-glycoprotein and drug pharmacokinetics.docVIP

 PAGE \* MERGEFORMAT 24 P-glycoprotein and drug pharmacokinetics Abstract ATP-binding cassette transporter protein as the impact of drugs in vivo an important factor in the process has been studied extensively, P-glycoprotein (P-gp) is one of the most important as a transporter. P-gp structure, characteristics and determine its tissue distribution in drug absorption, distribution, metabolism, and excretion in an important role. Understanding of P-gp in these effects help to increase the clinical use of drugs is reasonable. After nearly three decades of development, although the P-gp research approach has been more mature; however, the current study transporter is still much controversy exists, there are still many problems to be solved. This paper described the characteristics of P-gp and its impact on drug pharmacokinetics. Keywords: ATP-binding cassette transporter protein; P-glycoprotein; drug pharmacokinetics In recent years, ATP-binding cassette transporter protein in the process of drug effects in vivo have been studied extensively. P-glycoprotein (P-glycoprotein, P-gp) is one of the largest sub-system. The study found, P-gp distribution in many organizations, is an ATP-dependent membrane transporter, as a drug transporter and its role is similar to efflux pump can be of drugs from the cells inside and outside the row of Er Shi lower intracellular drug concentrations, thereby reduce the efficacy [1]. Therefore, P-gp with the substrate and the regulator can influence the interaction between the drug absorption, distribution, metabolism, excretion. Currently mainly used cell model (caco-2 cell line) and animal models (mdr knock-out mice) to study P-gp substrate for its pharmacokinetics, common regulator with cyclosporine A (CsA ), and verapamil. An understanding of ATP-binding cassette transporter protein family ATP-binding cassette transporter protein (ATP-binding cassette transporter, ABC) is a membrane glycop