Patients with breast cancer the expression of lymphocyte function associated antigen-clinical study.doc

 PAGE \* MERGEFORMAT 8 Patients with breast cancer the expression of lymphocyte function associated antigen-clinical study Abstract Objective: To investigate in patients with breast cancer, cancer organizations, the draining lymph node lymphocyte function-associated antigen cd11a, cd18, cd54 protein expression level and chemotherapy and traditional Chinese medicine Qi Yangxue Granule on the expression level. : Immunohistochemistry and flow cytometry in patients with breast cancer, cancer organizations, draining lymph node in cd11a, cd18, cd54 protein expression level in the chemotherapy before and after chemotherapy, and after serving Yiqi Yangxue Granule changes. Results: The breast cancer cd54 blood levels compared with healthy control group was significantly higher in cancer tissue lymphocytes cd11a, cd18, cd54 levels were significantly increased expression in breast cancer cells cd54 positive rate was 100% and a negative lymph nodes cd11a, cd18, cd54 expression levels were significantly higher than the positive lymph nodes. Conclusion: The level of adhesion molecules in patients with breast cancer was markedly abnormal, immune dysfunction, anti-cancer chemotherapy in the same time, adversely affect immune function, Yiqi Yangxue Granule can improve the adhesion of lymphocytes in breast cancer patients after chemotherapy features such as cellular immune function. Lymphocyte function-associated antigen (lymphocytefunctionassociatedantigen-1, lfa-1) is a membrane protein molecule is determined by α (cd11a, 180kd) and β (cd18, 95kd) more than two peptide chains composed of heterodimers (1 ). cd54 also known as intercellular adhesion molecule (intercellularadhesionmolecule-1, icam-1) as a single-chain glycoprotein, is lfa-1 ligand. Together they constitute an important component of integrin, and tumor immunity is closely related to, but its occurrence in breast cancer, has played a role in how the drug on their impact, it was not clear, in this pr