Patients with cerebral infarction peroxisome proliferator-activated receptor expression mRNA Creactive protein and its correlation.doc

 PAGE \* MERGEFORMAT 11 Patients with cerebral infarction peroxisome proliferator-activated receptor expression mRNA Creactive protein and its correlation Of: Lu Dong Lu Xiaochan Qin Zhijian Wei Shige [Abstract] cerebral infarction in elderly patients with peroxisome proliferator-activated receptor (PPAR) mRNA expression and its relationship with serum C-reactive protein (CRP) correlation. Method of sequential collection of disease within 3 d, met the inclusion criteria 64 patients with cerebral infarction in elderly, while collecting healthy matched 60 patients over the same period as the control group. by RT PCR method for the determination of fasting peripheral blood lymphocytes in both groups the expression of PPAR mRNA, determined by scattering rate of CRP content. Results cerebral infarction and PPAR mRNA expression in the control group were (0.321 + -0.038 and (0.843 + -0.074 difference between two groups was significant (P lt;0.01, serum CRP concentrations in patients with cerebral infarction (38.41 + -12.05mg / L, serum CRP concentration of the control group (5.53 +-2.12mg / L, the difference between the two groups was significant (P lt;0.01, the expression of PPAR mRNA in patients with cerebral infarction and serum CRP levels were negatively correlated (r =- 0.539, P lt;0.01. Conclusion onset patients with cerebral infarction within 3 d PPAR mRNA expression in peripheral blood lymphocytes decreased, and with serum CRP levels were negatively correlated, suggesting that PPAR may regulate CRP pathway was involved in the pathological aspects of cerebral inflammation, caused by tissue injury and promote thrombosis. [Keywords:] infarction, peroxisome proliferator-activated receptor , C-reactive protein Peroxisome proliferator-activated receptor (PPAR) can be expressed in a variety of tissues in the body, the body in many physiological and pathophysiological processes. In vitro cell culture studies have shown that, PPAR activation can inhibit i