Patients with lung cancer CEA CYFRA21-1 NSE SCC Clinical Significance.doc

 PAGE \* MERGEFORMAT 12 Patients with lung cancer CEA CYFRA21-1 NSE SCC Clinical Significance [Abstract] Objective To investigate patients with lung cancer in carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), neuron-specific enolase (NSE), squamous cell carcinoma antigen (SCC) Clinical significance . Methods chemiluminescence confirmed by pathology or cytology, 137 cases of lung cancer patients, 30 patients with benign lung disease, serum CEA, CYFRA21-1, NSE, SCC level, calculating the positive rate, sensitivity and specificity and analyzed statistically. Results of 4 patients with lung cancer tumor markers were significantly higher (P lt;0.01). CEA in lung adenocarcinoma, SCC squamous cell carcinoma in the lung, NSE in small cell lung cancer in the highest level, and The difference between other groups was statistically significant. CYFRA21-1 levels in small cell lung cancer group and non-small cell lung cancer group, the difference was statistically significant .4 serum markers combined detection, sensitivity increased. Conclusion 4 tumor markers material on the clinical diagnosis of lung cancer are of clinical significance, and the combined detection of more help to the diagnosis and differential diagnosis of lung cancer. [Keywords:] lung cancer; tumor markers; carcinoembryonic antigen; cytokeratin 19 fragment; neuron-specific enolase; squamous cell carcinoma antigen ABSTRACT: ObjectiveTo evaluate the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA), cytokeratins 21-1 (CYFRA21-1), neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) in patients with lung cancer.MethodsThe serum levels of CEA, CYFRA21-1, NSE and SCC were measured by chemiluminescence immunoassay in 137 patients with lung cancer, which was confirmed with pathological or cytological method, and 30 patients with benign lung diseases. Then the positive rate, sensitivity rate and specificity rate were calculated.ResultsThe levels