Pentoxifylline on sperm motility and fertilization capacity of the.doc

 PAGE \* MERGEFORMAT 26 Pentoxifylline on sperm motility and fertilization capacity of the Keywords: of pentoxifylline;, sperm capacitation;, acrosome reaction;, fertilization Good semen quality and sperm motility is an important guarantee for the success of fertilization. In the male factor infertility patients, sperm dysfunction is an important one of the reasons, such as oligospermia, weak sperm disorders, defects of sperm acrosome reaction, so that couples can not be normal fertilization, but to take assisted reproductive technology treatment . Assisted reproductive technology in male infertility treatment, use of in vitro fertilization to improve sperm motility and the ability to research. Many substances such as serum, peritoneal fluid, follicular fluid, and other chemical modification of drugs such as progesterone, adenosine analogues and methylxanthine are all being used to improve human sperm movement and fertilization ability. Methylxanthine derivatives such as caffeine, pentoxifylline (pentoxifylline, PF) is a more recent study of sperm function for a class of objects. Methylxanthines are phosphodiesterase inhibitors, by inhibiting phosphodiesterase activity, reducing the decomposition of cAMP, thereby enhancing the concentration of cAMP in the sperm [1]. In some hypotheses cAMP believed to be involved in sperm hyperactivated movement (hyperactivated motility, HAM) and the sperm acrosome reaction (acrosome reaction, AR) signal transduction [2]. In the above-mentioned active, PF and caffeine compared to the role of longer duration, water-soluble higher, therefore more attention. PF has been used in clinical treatment of cardiovascular diseases, in assisted reproduction has also been used to treat male factor infertility. With regard to the impact of PF on sperm function studies have reported more, the author in relation to an overview of progress. 1 PF and the sperm motility With regard to the role of PF on spe