Pharmacogenomics in clinical individualized medication guide for.doc

 PAGE \* MERGEFORMAT 13 Pharmacogenomics in clinical individualized medication guide for [Abstract] Objective To introduce pharmacogenomics clinical individualized medication guide. Methods to read and analyze published in recent years, the domestic genomics on drug-related article on pharmacogenomics in guiding the clinical role of individual drugs to be summed up, sum up. Results and discussion pharmacogenomics After 10 years of development, in drug metabolism, transport and pharmacological research on the role of genetic polymorphism has seen much progress, some major breakthrough drugs, such as the prevention of aminoglycoside deafness problem But more drug research also are in the initial stage, to be more in-depth research. With pharmacogenomics research methods and new technology continues to improve, as well as individual gene chips for drug research and development, in the near future can be achieved by genetic selection on the therapeutic drug medical model of individualized medicine. [Keywords:] pharmacogenomics personalized medicine side effects effect of genetic polymorphism As early as 50 years in the 20th century, we know that genetic factors influence drug response, a typical example is the broad bean disease, the cause of genetic defects leading to glucose 6 - phosphate dehydrogenase (G6PD) the lack of, or active low, causing a series of biochemical metabolic abnormalities in patients with asymptomatic under normal circumstances, but in eating beans or use of antimalarial drugs primaquine morpholine and other kinds of drugs with a strong oxidation occurs after the acute hemolytic reaction; There is also the role of acetylation of isoniazid, acetylation at different rates from individual to individual, leading to different individuals when using the same dose of isoniazid efficacy difference, or if there were toxicity phenomenon. The 20th century, 90 years, the emergence of pharmacogenomics makes us different individuals differences in drug r